1-[3-[[5-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy]phenyl]propan-1-one

Base Information

Chemical Name:1-[3-[[5-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy]phenyl]propan-1-one
CAS No.:174258-40-3
Molecular Formula:C₂₁H₁₈F₃NO₃
Molecular Weight:389.374
Hs Code.:
DSSTox Substance ID:DTXSID901129195

Synonyms:SCHEMBL8546401;SQHJPNFELHPEBL-UHFFFAOYSA-N;DTXSID901129195;1-[3-[[5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy]phenyl]propan-1-one;1-[3-[[5-Methyl-2-[4-(trifluoromethyl)phenyl]-4-oxazolyl]methoxy]phenyl]-1-propanone;174258-40-3

Suppliers and Price of 1-[3-[[5-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy]phenyl]propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-[[5-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy]phenyl]propan-1-one

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:389.12387792
Heavy Atom Count:28
Complexity:520

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)C1=CC(=CC=C1)OCC2=C(OC(=N2)C3=CC=C(C=C3)C(F)(F)F)C

Technology Process of 1-[3-[[5-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy]phenyl]propan-1-one

There total 7 articles about 1-[3-[[5-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy]phenyl]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

jones' reagent: jones' reagent

: 925-90-6
ethylmagnesium bromide

: 174258-10-7
3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

: 174258-40-3
1-{3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)phenyl}propan-1-one

Guidance literature:: In tetrahydrofuran; acetone;

Reference yield:

: 174258-36-7
1-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-propan-1-ol

: 174258-40-3
1-{3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)phenyl}propan-1-one

Guidance literature:: With jones reagent; In acetone; at 5 ℃; for 0.5h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 174258-40-3
1-{3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)phenyl}propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

4: tetrahydrofuran / 0.5 h / 0 °C

5: Jones reagent / acetone / 0.5 h / 5 °C

With hydrogenchloride; jones reagent; potassium carbonate; trichlorophosphate; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; 1: Condensation / 2: Chlorination / 3: Alkylation / 4: Grignard reaction / 5: Oxidation;
DOI:10.1021/jm990476x