ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate

Base Information

Chemical Name:ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate
CAS No.:1380336-89-9
Molecular Formula:C₁₉H₂₆N₄O₄
Molecular Weight:374.44
Hs Code.:

Synonyms:ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate

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Chemical Property of ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate

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Technology Process of ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate

There total 3 articles about ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1313705-91-7
tert-butyl (R)-4-benzyl-1,2,3-oxathiazolidine-3-carboxylate-2,2-dioxide

: 623-47-2
propynoic acid ethyl ester

: 1380336-89-9
ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: tert-butyl (R)-4-benzyl-1,2,3-oxathiazolidine-3-carboxylate-2,2-dioxide; With sodium azide; In water; tert-butyl alcohol; at 120 ℃; for 0.166667h; Sealed tube; Microwave irradiation;

propynoic acid ethyl ester; With copper; copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 70 ℃; for 0.25h; regioselective reaction; Sealed tube; Microwave irradiation;
DOI:10.1039/c2cc32392c

Reference yield:

: C₁₄H₁₉NO₄S

: 1380336-89-9
ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0 °C

2.1: sodium azide / water; tert-butyl alcohol / 0.17 h / 120 °C / Sealed tube; Microwave irradiation

2.2: 0.25 h / 70 °C / Sealed tube; Microwave irradiation

With ruthenium trichloride; sodium periodate; sodium azide; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c2cc32392c

Reference yield:

: 106454-69-7
N-tert-butoxycarbonyl-D-Phenylalaninol

: 1380336-89-9
ethyl (R)-1-(2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / acetonitrile / 0.92 h / -40 °C / Inert atmosphere

1.2: -40 - 20 °C / Inert atmosphere

2.1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0 °C

3.1: sodium azide / water; tert-butyl alcohol / 0.17 h / 120 °C / Sealed tube; Microwave irradiation

3.2: 0.25 h / 70 °C / Sealed tube; Microwave irradiation

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium azide; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c2cc32392c