4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride

Base Information

Chemical Name:4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride
CAS No.:99280-97-4
Molecular Formula:C₂₀H₁₈N₄O*ClH
Molecular Weight:366.85
Hs Code.:

Synonyms:4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride

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Chemical Property of 4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride

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Technology Process of 4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride

There total 8 articles about 4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 99280-96-3
γ-oxo-2-phenyl-1-(phenylmethyl)-1H-imidazole-4-butanoic acid

: 99280-97-4
4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride

Guidance literature:: With hydrogenchloride; hydrazine hydrate; for 3h; Heating;
DOI:10.1021/jm00152a015

Reference yield:

: 100-39-0
benzyl bromide

: 99280-97-4
4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / KOH / dimethylformamide / 5 h / 55 °C

2: MnO₂ / tetrahydrofuran / 1.5 h / Heating

3: p-toluenesulfonic acid monohydrate / dioxane / 1.5 h / Heating

4: KOH / tetrahydrofuran; methanol / 2 h / 23 °C

5: aq. 80 percent AcOH / 2 h / Heating

6: 20percent HCl / propan-1-ol / 4 h / Heating

7: 60 percent / hydrazine hydrate, aq. HCl / 3 h / Heating

With hydrogenchloride; manganese(IV) oxide; potassium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; propan-1-ol; N,N-dimethyl-formamide;
DOI:10.1021/jm00152a015

Reference yield:

: 99280-85-0
1-benzyl-2-phenyl-1H-imidazole-4-carbaldehyde

: 99280-97-4
4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonic acid monohydrate / dioxane / 1.5 h / Heating

2: KOH / tetrahydrofuran; methanol / 2 h / 23 °C

3: aq. 80 percent AcOH / 2 h / Heating

4: 20percent HCl / propan-1-ol / 4 h / Heating

5: 60 percent / hydrazine hydrate, aq. HCl / 3 h / Heating

With hydrogenchloride; potassium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; propan-1-ol;
DOI:10.1021/jm00152a015