99280-85-0

Upstream product

• 15421-92-8 N-benzylbenzamidine 
• 1314079-20-3 N-allyl-N-benzyl-phenylamidine 
• 4383-22-6 Allylbenzylamine 
• 100-47-0 benzonitrile 
• 100-39-0 benzyl bromide 
• 68282-47-3 2-phenyl-1H-imidazole-4-carbaldehyde 
• 7471-86-5 methyl benzimidate 
• 100-46-9 benzylamine 
• 99280-80-5 (1-Benzyl-2-phenyl-1H-imidazol-4-yl)-methanol 
• 43002-54-6 (2-phenyl-1H-imidazol-4-yl)-methanol 

Downstream Products

• 99280-87-2 α-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-4-morpholineacetonitrile 
• 99280-97-4 4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride 
• 99280-91-8 2-(4-morpholinyl)-2-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>pentanedinitrile 
• 99280-96-3 γ-oxo-2-phenyl-1-(phenylmethyl)-1H-imidazole-4-butanoic acid 
• 99280-99-6 6-(1-Benzyl-2-phenyl-1H-imidazol-4-yl)-2H-pyridazin-3-one 
• 99280-93-0 γ-oxo-2-phenyl-1-(phenylmethyl)-1H-imidazole-4-butanenitrile 

Relevant academic research and scientific papers

Copper-catalyzed intramolecular dehydrogenative aminooxygenation: Direct access to formyl-substituted aromatic N-heterocycles

A direct synthesis of carbaldehydes through intramolecular dehydrogenative aminooxygenation has been developed. The process uses a catalytic amount of copper(II) in DMF or DMA under oxygen and does not require additional oxidants (see scheme). Mechanistic studies suggest that the carbonyl oxygen atom of the aldehyde is derived from oxygen through a copper-mediated oxygen activation process via a peroxy-copper(III) intermediate. Copyright

PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DISEASE IN WHICH MITOCHONDRIAL BENZODIAZEPINE RECEPTOR PARTICIPATES

A compound represented by formula (I) (wherein ring A is a nitrogen-containing ring which may have a substituent(s), E is a binding bond or a spacer of which main chain has an atom number of 1-8, Q is a hydrogen atom, a hydrocarbon group which may have a

A New Regioselective Synthesis of 1,2,5-Trisubstituted 1H-Imidazoles and Its Application to the Development of Eprosartan

A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with 2-halo-3-alkoxy-2-propenals. The reaction is highly regioselective with ratios of 1,2,5:1,2,4-imidazolecarboxaldehydes ranging from 85:15 to 100: 0. This methodology could be extended with similar results to the synthesis of imidazole-5-nitriles by the reaction of 2-bromo-3-methoxy-2-propenenitrile with N-monosubstituted amidines.