99280-85-0

Basic information

• Product Name: 1-benzyl-2-phenyl-1H-imidazole-4-carbaldehyde
• Synonyms: 1-benzyl-2-phenyl-1H-imidazole-4-carbaldehyde
• CAS NO: 99280-85-0
• Molecular Weight: 262.311
• Mol File: 99280-85-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-benzyl-2-phenyl-1H-imidazole-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2-phenyl-1H-imidazole-4-carbaldehyde(99280-85-0)
• EPA Substance Registry System: 1-benzyl-2-phenyl-1H-imidazole-4-carbaldehyde(99280-85-0)

Safety Data

• Hazardous Substances Data: 99280-85-0(Hazardous Substances Data)

Upstream product

• 15421-92-8 N-benzylbenzamidine 
• 1314079-20-3 N-allyl-N-benzyl-phenylamidine 
• 4383-22-6 Allylbenzylamine 
• 100-47-0 benzonitrile 
• 100-39-0 benzyl bromide 
• 68282-47-3 2-phenyl-1H-imidazole-4-carbaldehyde 
• 43002-54-6 (2-phenyl-1H-imidazol-4-yl)-methanol 
• 7471-86-5 methyl benzimidate 
• 100-46-9 benzylamine 
• 99280-80-5 (1-Benzyl-2-phenyl-1H-imidazol-4-yl)-methanol 

Downstream Products

• 99280-97-4 4,5-dihydro-6-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-3(2H)-pyridazinone hydrochloride 
• 99280-91-8 2-(4-morpholinyl)-2-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>pentanedinitrile 
• 99280-96-3 γ-oxo-2-phenyl-1-(phenylmethyl)-1H-imidazole-4-butanoic acid 
• 99280-99-6 6-(1-Benzyl-2-phenyl-1H-imidazol-4-yl)-2H-pyridazin-3-one 
• 99280-93-0 γ-oxo-2-phenyl-1-(phenylmethyl)-1H-imidazole-4-butanenitrile 
• 99280-87-2 α-<2-phenyl-1-(phenylmethyl)-1H-imidazol-4-yl>-4-morpholineacetonitrile 

Relevant articles and documents

Copper-catalyzed intramolecular dehydrogenative aminooxygenation: Direct access to formyl-substituted aromatic N-heterocycles

A direct synthesis of carbaldehydes through intramolecular dehydrogenative aminooxygenation has been developed. The process uses a catalytic amount of copper(II) in DMF or DMA under oxygen and does not require additional oxidants (see scheme). Mechanistic studies suggest that the carbonyl oxygen atom of the aldehyde is derived from oxygen through a copper-mediated oxygen activation process via a peroxy-copper(III) intermediate. Copyright

A New Regioselective Synthesis of 1,2,5-Trisubstituted 1H-Imidazoles and Its Application to the Development of Eprosartan

A new method is presented for the preparation of 1,2-disubstitued-1H-imidazole-5-carboxaldehydes by the reaction of N-monosubstituted amidines with 2-halo-3-alkoxy-2-propenals. The reaction is highly regioselective with ratios of 1,2,5:1,2,4-imidazolecarboxaldehydes ranging from 85:15 to 100: 0. This methodology could be extended with similar results to the synthesis of imidazole-5-nitriles by the reaction of 2-bromo-3-methoxy-2-propenenitrile with N-monosubstituted amidines.