4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole

Base Information

• Chemical Name: 4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole
• CAS No.: 94377-89-6
• Molecular Formula: C₁₉H₁₈N₂
• Molecular Weight: 274.365
• Mol file: 94377-89-6.mol

Synonyms:4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole

Chemical Property of 4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole

There total 16 articles about 4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2-bromocyclohex-1-en-1-yl)(phenyl)methanone (1001386-09-9) + phenylhydrazine (100-63-0) → 4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole (94377-89-6)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium t-butanolate; In toluene; at 125 ℃; for 20h; Inert atmosphere; Autoclave;

DOI:10.1002/aoc.2900

Reference yield: 71.0%

2-methylenecyclohexan-1-yl phenyl ketone (39207-77-7) + phenylhydrazine (100-63-0) → C20H22N2O + 4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole (94377-89-6)

Guidance literature:

2-methylenecyclohexan-1-yl phenyl ketone; phenylhydrazine; With acetic acid; In methanol; chlorobenzene; at 50 ℃; for 3h; Inert atmosphere;

With 1,10-Phenanthroline; palladium diacetate; acetic acid; In methanol; chlorobenzene; at 60 ℃; for 12h;

DOI:10.1021/acs.orglett.5b01127

Reference yield: 70.0%

iodobenzene (591-50-4) + 1-phenyl-4,5,6,7-tetrahydro-1H-indazole (14714-06-8) → 4,5,6,7-tetrahydro-1,3-diphenyl-1H-indazole (94377-89-6)

Guidance literature:

With 1,10-Phenanthroline; palladium diacetate; caesium carbonate; In toluene; at 160 ℃; for 72h; Sealed tube;

DOI:10.1039/c3sc50184a

upstream raw materials:

phenylhydrazine

2-Benzoylcyclohexanone

1,3-diphenyl-3a,4,5,6,7,7a-hexahydro-1H-indazole

cyclohexanone