(7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

Base Information

Chemical Name:(7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate
CAS No.:1027002-73-8
Molecular Formula:C₂₄H₂₈N₂O₄
Molecular Weight:408.497
Hs Code.:

Synonyms:(7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

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Chemical Property of (7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

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Technology Process of (7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

There total 1 articles about (7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1027002-69-2
(8R,9R)-2,3-dimethyl-7-oxo-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

: 676-58-4
methylmagnesium chloride

: 1027002-73-8
(7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

Guidance literature:: (8R,9R)-2,3-dimethyl-7-oxo-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate; methylmagnesium chloride; In tetrahydrofuran; at -52 - -45 ℃; for 2h;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1027002-73-8
(7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

: 112981-50-7
2-methoxyethyl trifluoromethanesulphonate

: 1027002-71-6
(7R,8R,9R)-7-(2-methoxyethoxy)-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate

Guidance literature:: (7R,8R,9R)-7-hydroxy-2,3,7-trimethyl-9-phenyl-8,9-dihydro-7H-imidazo[1,2-a]pyrano[2,3-c]pyridin-8-yl pivalate; 2-methoxyethyl trifluoromethanesulphonate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -15 ℃; for 2h;

With ammonium chloride; In tetrahydrofuran;