(R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

Base Information

Chemical Name:(R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester
CAS No.:1624283-92-6
Molecular Formula:C₂₈H₃₈BN₃O₄
Molecular Weight:491.438
Hs Code.:

Synonyms:(R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

Suppliers and Price of (R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

There total 6 articles about (R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1310383-72-2,179324-87-9
(aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

: 1624283-79-9
2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetic acid

: 1624283-92-6
(R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

: 1624283-50-6
N-isopentyl-2-(2-oxo-3-phenylamino-2H-pyridin-1-yl)acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 - 20 ℃; for 3h;
DOI:10.1002/cmdc.201402075

Reference yield:

: 52200-48-3
3-bromo-2-chloropyridine

: 1624283-92-6
(R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

: 1624283-50-6
N-isopentyl-2-(2-oxo-3-phenylamino-2H-pyridin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

3.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

5.1: lithium hydroxide / ethanol; water / 4 h / 0 - 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -15 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium hydride; sodium hydride; benzotriazol-1-ol; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402075

Reference yield:

: 52200-49-4
3-bromo-2-(phenylmethoxy)pyridine

: 1624283-92-6
(R)-1-{2-[2-oxo-3-(phenylamino)pyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid pinanediol ester

: 1624283-50-6
N-isopentyl-2-(2-oxo-3-phenylamino-2H-pyridin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

4: lithium hydroxide / ethanol; water / 4 h / 0 - 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -15 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; sodium t-butanolate; In methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402075