52200-49-4

Basic information

• Product Name: 2-(BENZYLOXY)-3-BROMOPYRIDINE
• Synonyms: 2-(BENZYLOXY)-3-BROMOPYRIDINE;3-bromo-2-phenylmethoxypyridine
• CAS NO: 52200-49-4
• Molecular Formula: C₁₂H₁₀BrNO
• Molecular Weight: 264.1179
• Product Categories: Heterocyclic Compounds;Pyridines
• Mol File: 52200-49-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 325.8 °C at 760 mmHg
• Flash Point: 150.9 °C
• Appearance: /
• Density: 1.438
• Vapor Pressure: 0.000426mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• PKA: 1.56±0.22(Predicted)
• CAS DataBase Reference: 2-(BENZYLOXY)-3-BROMOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BENZYLOXY)-3-BROMOPYRIDINE(52200-49-4)
• EPA Substance Registry System: 2-(BENZYLOXY)-3-BROMOPYRIDINE(52200-49-4)

Safety Data

• Hazardous Substances Data: 52200-49-4(Hazardous Substances Data)

Usage

General Description

2-(Benzyloxy)-3-bromopyridine is a chemical compound with the molecular formula C12H9BrNO. It is a brominated pyridine derivative with a benzyl ether group attached to the second carbon of the pyridine ring. This chemical is commonly used as a building block in organic synthesis and pharmaceutical research. It can be utilized in the production of biologically active compounds and as a starting material for the synthesis of various heterocyclic compounds. Additionally, 2-(Benzyloxy)-3-bromopyridine has potential applications in the fields of medicinal chemistry and drug discovery due to its unique structure and properties.

InChI:InChI=1/C12H10BrNO/c13-11-7-4-8-14-12(11)15-9-10-5-2-1-3-6-10/h1-8H,9H2

Upstream product

• 13466-43-8 3-bromo-pyridin-2-ol 
• 100-39-0 benzyl bromide 
• 52200-48-3 3-bromo-2-chloropyridine 
• 100-51-6 benzyl alcohol 
• 13466-43-8 3-bromopyridin-2(1H)-one 

Downstream Products

• 637349-33-8 C₂₆H₂₀N₂O₂ 
• 52200-48-3 3-bromo-2-chloropyridine 
• 1072952-41-0 (2-benzyloxy-3-pyridyl)boronic acid 
• 1624283-60-8 2-(benzyloxy)-N-phenylpyridin-3-amine 
• 1006052-58-9 2-(benzyloxy)-3-(piperidin-1-yl)pyridine 
• 1256488-81-9 methyl 2-[2-[5-(2-benzyloxy-3-pyridyl)-3-tert-butyl-2-methoxyphenyl]ethynyl]-5-[bis(methylsulfonyl)amino]benzoate 
• 1256489-09-4 C₃₃H₃₆N₂O₇S 
• 1256489-08-3 C₃₃H₃₄N₂O₇S 
• 1256489-07-2 C₃₂H₃₄N₄O₅S 
• 1309857-66-6 C₃₃H₃₄N₂O₅S 
• 1256488-83-1 N-[3-[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]-1-oxo-isochromen-7-yl]-N-methylsulfonylmethanesulfonamide 
• 1256488-98-8 C₂₆H₃₂N₂O₆S 
• 1256489-18-5 C₃₃H₃₈N₂O₆S 
• 1256489-02-7 C₃₂H₃₀N₂O₃ 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase

Presented here are initial structure-activity relationship (SAR) studies on a series of novel heteroaryl fused tetracyclic indole-based inhibitors of the hepatitis C viral polymerase, NS5B. The introduction of alternative heterocyclic moieties into the indolo-fused inhibitor class significantly expands the reported SAR and resulted in the identification of pyridino analogs, typified by compounds 44 and 45 that displayed excellent potency against the NS5B polymerase of both HCV 1a and HCV 1b genotypes.

A FACILE SYNTHESIS OF BROMO-2-ALKOXYPYRIDINES

Several bromo-2-methoxypyridines 2a-2e and bromo-2-benzyloxypyridines 2a'-2e' were synthesised by the reaction of bromo-substituted 2-pyridones 1 which were reacted with alkyl halides in the presence of silver carbonate in benzene.