C₁₈H₂₁BrO₈

Base Information

• Chemical Name: C₁₈H₂₁BrO₈
• CAS No.: 87907-08-2
• Molecular Formula: C₁₈H₂₁BrO₈
• Molecular Weight: 445.264
• Mol file: 87907-08-2.mol

Synonyms:C₁₈H₂₁BrO₈

Chemical Property of C₁₈H₂₁BrO₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₁BrO₈

There total 9 articles about C₁₈H₂₁BrO₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (acetyl 2,4-di-O-acetyl-3-O-benzyl-α,β-L-idopyranoside)uronate (93382-47-9) → C18H21BrO8 (87907-08-2)

Guidance literature:

With hydrogen bromide; acetic acid; In dichloromethane; at -5 - 5 ℃; for 2h; Industry scale;

Reference yield:

1,2:5,6-di-O-isopropylidene-α-D-glucofuranose (582-52-5) → C18H21BrO8 (87907-08-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium hydroxide / tetrabutylammomium bromide / toluene / 20 °C / Industry scale

2.1: water; acetic acid / 40 - 45 °C / Industry scale

3.1: sodium hydrogencarbonate; 1,3-dichloro-5,5-dimethylhydantoin / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; tetrahydrofuran / -5 - 0 °C / Industry scale

3.2: pH 2 - 3 / Industry scale

4.1: potassium carbonate / acetone / 20 °C / Industry scale

5.1: pyridine / dichloromethane / -50 - -45 °C / Industry scale

6.1: sodium 2,2,2-trifluoroacetate / N,N-dimethyl-formamide / 75 - 80 °C / Industry scale

6.2: 12 h / 20 °C / Industry scale

7.1: trifluoroacetic acid / water / 10 - 15 °C / Industry scale

8.1: pyridine / 0 - 20 °C / Industry scale

9.1: hydrogen bromide; acetic acid / dichloromethane / 2 h / -5 - 5 °C / Industry scale

With pyridine; 1,3-dichloro-5,5-dimethylhydantoin; water; hydrogen bromide; sodium 2,2,2-trifluoroacetate; sodium hydrogencarbonate; potassium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutylammomium bromide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

(1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol (22529-61-9) → C18H21BrO8 (87907-08-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate; 1,3-dichloro-5,5-dimethylhydantoin / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; tetrahydrofuran / -5 - 0 °C / Industry scale

1.2: pH 2 - 3 / Industry scale

2.1: potassium carbonate / acetone / 20 °C / Industry scale

3.1: pyridine / dichloromethane / -50 - -45 °C / Industry scale

4.1: sodium 2,2,2-trifluoroacetate / N,N-dimethyl-formamide / 75 - 80 °C / Industry scale

4.2: 12 h / 20 °C / Industry scale

5.1: trifluoroacetic acid / water / 10 - 15 °C / Industry scale

6.1: pyridine / 0 - 20 °C / Industry scale

7.1: hydrogen bromide; acetic acid / dichloromethane / 2 h / -5 - 5 °C / Industry scale

With pyridine; 1,3-dichloro-5,5-dimethylhydantoin; hydrogen bromide; sodium 2,2,2-trifluoroacetate; sodium hydrogencarbonate; potassium carbonate; acetic acid; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

(1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol

3-O-benzyl-1,2-5,6-O-diisopropylidene-α-D-glucofuranose

methyl 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranosiduronate

Downstream raw materials:

methyl 3-O-benzyl-β-L-idopyranuronate 1,2-(tert-butyl orthoacetate)

methyl 3-O-benzyl-4-O-monochloroacetyl-β-L-idopyranuronate 1,2-(tert-butyl orthoacetate)