93382-47-9Relevant articles and documents
PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
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, (2013/02/28)
Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.
Synthesis of a polysulfated heparin degradation product
Kuszmann, Janusz,Medgyes,Boros
, p. 344 - 348 (2007/10/03)
Two suitable methods for the synthesis of the heparin degradation product 2,5-anyhydro-3-O-(α-L-ido-pyranosyluronate)-D-mannitol hexa O-sulfate are reported. The synthesis pathways start from D-glucose and D-glucosamine.
New accesses to L-iduronyl synthons
Lubineau,Gavard,Alais,Bonnaffé
, p. 307 - 311 (2007/10/03)
(PhS)3CLi adds with a total L-ido selectivity onto 3-O-benzyl-1,2-O- isopropylidene-α-D-xylo-dialdose 2, opening the way to the most efficient preparation of 1,2,4-tri-O-acetyl-3-O-benzyl-L-iduronyl synthon 8. Alternatively, in view of combinat