acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester

Base Information

• Chemical Name: acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester
• CAS No.: 925426-04-6
• Molecular Formula: C₁₉H₃₁NO₅Si
• Molecular Weight: 381.544
• Mol file: 925426-04-6.mol

Synonyms:acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester

Chemical Property of acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester

There total 3 articles about acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-N-benzyloxycarbonyl-2-amino-3-hydroxypropyl acetate (124044-68-4) + tert-butyldimethylsilyl chloride (18162-48-6) → acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester (925426-04-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol062643a

Reference yield:

N-Benzyloxycarbonyl-1,3-dihydroxy-2-aminopropane (71811-26-2) → acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester (925426-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / pig pancreatic lipase / 3 h / 20 °C

2: imidazole / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; pig pancreatic lipase; In dichloromethane;

DOI:10.1021/ol062643a

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → acetic acid 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl ester (925426-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / triethylamine / ethanol / 0 - 20 °C

2: 86 percent / pig pancreatic lipase / 3 h / 20 °C

3: imidazole / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; pig pancreatic lipase; triethylamine; In ethanol; dichloromethane;

DOI:10.1021/ol062643a

upstream raw materials:

(2R)-N-benzyloxycarbonyl-2-amino-3-hydroxypropyl acetate

tert-butyldimethylsilyl chloride

N-Benzyloxycarbonyl-1,3-dihydroxy-2-aminopropane

benzyl chloroformate

Downstream raw materials:

(S)-N-benzyloxycarbonyl-2-(t-butyldimethylsilyloxymethyl)aziridine

3-(t-butyldimethylsiloxy)-2-(benzyloxycarbonylamino)propan-1-ol