N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

Base Information

Chemical Name:N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride
CAS No.:110143-28-7
Molecular Formula:C₃₅H₄₆NO₄Si*Cl
Molecular Weight:608.293
Hs Code.:

Synonyms:N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

Suppliers and Price of N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

There total 9 articles about N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 110143-27-6
N-benzyl-8β-(hydroxymethyl)-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine

: 110143-28-7
N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h;
DOI:10.1021/jm00394a016

Reference yield:

: 93-97-0
benzoic acid anhydride

: 110143-28-7
N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 99 percent / benzene / 7 h / Heating

3: 64 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / Heating

4: 1.) KH, 2.) n-BuLi

5: 97 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -78 - -40 °C

6: 52 percent / silica gel / CHCl₃ / 48 h

7: 100 percent / NaBH₄ / methanol; benzene / 0.5 h / Ambient temperature

8: 99 percent / Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 0.08 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; silica gel; potassium hydride; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; benzene;
DOI:10.1021/jm00394a016

Reference yield:

: 7679-18-7
N-desmethylthebaine hydrochloride

: 110143-28-7
N-benzyl-N,8β-methano-7α-<<(tert-butyldimethylsilyl)oxy>methyl>-endo-ethylenetetrahydronorthebaine quaternary chloride

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 99 percent / benzene / 7 h / Heating

3: 64 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / Heating

4: 1.) KH, 2.) n-BuLi

5: 97 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -78 - -40 °C

6: 52 percent / silica gel / CHCl₃ / 48 h

7: 100 percent / NaBH₄ / methanol; benzene / 0.5 h / Ambient temperature

8: 99 percent / Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 0.08 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; silica gel; potassium hydride; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; benzene;
DOI:10.1021/jm00394a016