tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate
CAS No.:907611-33-0
Molecular Formula:C₂₆H₃₈N₂O₃
Molecular Weight:426.599
Hs Code.:

Synonyms:tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

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Chemical Property of tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

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Technology Process of tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

There total 10 articles about tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 907611-33-0
tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: methyl 5-(aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridine-3-carboxylate; With diisobutylaluminium hydride; In toluene; at -78 - 0 ℃; for 0.75h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; isopropyl alcohol; toluene; at 20 ℃; for 0.0833333h;

di-tert-butyl dicarbonate; In tetrahydrofuran; water; isopropyl alcohol; toluene; at 20 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₂₁H₃₀N₂O

: 907611-33-0
tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm101236h

Reference yield:

: 96798-17-3
5,5-dimethyl-3-oxohexanenitrile

: 907611-33-0
tert-butyl {[2-(2,2-dimethylpropyl)-6-ethyl-5-(hydroxymethyl)-4-(4-methylphenyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine; acetic acid / toluene / 8 h / Reflux

2.1: acetic acid / 1 h / 80 °C

3.1: ammonium cerium (IV) nitrate / water; acetone

4.1: ammonia; hydrogen / tetrahydrofuran; methanol / 3750.38 Torr

5.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

5.2: 0 - 20 °C

6.1: sodium hydroxide / tetrahydrofuran / 20 °C

With piperidine; ammonium cerium (IV) nitrate; ammonia; hydrogen; diisobutylaluminium hydride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; water; acetone; toluene; 1.1: Knoevenagel condensation;
DOI:10.1021/jm101236h