C₂₇H₃₅N

Base Information

• Chemical Name: C₂₇H₃₅N
• CAS No.: 1376191-20-6
• Molecular Formula: C₂₇H₃₅N
• Molecular Weight: 373.582
• Mol file: 1376191-20-6.mol

Synonyms:C₂₇H₃₅N

Chemical Property of C₂₇H₃₅N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₇H₃₅N

There total 6 articles about C₂₇H₃₅N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-decyne (764-93-2) + (S)-2-phenylpyrrolidine (1006-64-0,56523-47-8,56586-11-9,59347-91-0) + benzaldehyde (100-52-7) → C27H35N (1376191-20-6)

Guidance literature:

With zinc(II) iodide; In toluene; at 90 ℃; for 10h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol300717e

Reference yield:

3-benzoylpropionic acid methyl ester (25333-24-8) → C27H35N (1376191-20-6)

Guidance literature:

Multi-step reaction with 4 steps

1: borane-THF; Trimethyl borate; (S)-diphenylprolinol / tetrahydrofuran / 3 h / 0 - 25 °C

2: methanesulfonyl chloride / dichloromethane / 2 h / -10 °C

3: Wilkinson's catalyst / water; acetonitrile / 5 h / Inert atmosphere; Reflux

4: zinc(II) iodide / toluene / 10 h / 90 °C / Inert atmosphere

With Wilkinson's catalyst; borane-THF; Trimethyl borate; (S)-diphenylprolinol; methanesulfonyl chloride; zinc(II) iodide; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;

DOI:10.1021/ol300717e

Reference yield:

(2S)-N-allyl-2-phenylpyrrolidine (1376191-46-6) → C27H35N (1376191-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Wilkinson's catalyst / water; acetonitrile / 5 h / Inert atmosphere; Reflux

2: zinc(II) iodide / toluene / 10 h / 90 °C / Inert atmosphere

With Wilkinson's catalyst; zinc(II) iodide; In water; toluene; acetonitrile;

DOI:10.1021/ol300717e

upstream raw materials:

C₁₀H₁₁N

1-decyne

(S)-2-phenylpyrrolidine

benzaldehyde

Downstream raw materials:

C₁₀H₁₁N

(R)-1-phenylundeca-1,2-diene

(S)-1-phenylundeca-1,2-diene

(S)-2-phenylpyrrolidine