5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine

Base Information

• Chemical Name: 5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine
• CAS No.: 136743-12-9
• Molecular Formula: C₁₆H₁₈N₂O₄S
• Molecular Weight: 334.396
• Mol file: 136743-12-9.mol

Synonyms:5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine

Chemical Property of 5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine

There total 5 articles about 5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-benzylthio-1-(3,5-di-O-p-chlorobenzoyl-2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine (136743-09-4) → 5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine (136743-12-9)

Guidance literature:

With ammonia; In methanol; at 5 ℃; for 28h;

DOI:10.1002/jhet.5570280450

Reference yield:

5-benzylthio-1,2-dihydro-2-oxopyrazine (136743-01-6) → 5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine (136743-12-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / (NH₄)2SO₄ / 1.5 h / Heating

2: 0.43 g / 0.33 h / 95 - 110 °C / 0.05 Torr

3: 87 percent / NH₃ / methanol / 28 h / 5 °C

With ammonium sulfate; ammonia; In methanol;

DOI:10.1002/jhet.5570280450

Reference yield:

5-benzylthio-2-(trimethylsilyloxy)pyrazine (136743-08-3) → 5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine (136743-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.43 g / 0.33 h / 95 - 110 °C / 0.05 Torr

2: 87 percent / NH₃ / methanol / 28 h / 5 °C

With ammonia; In methanol;

DOI:10.1002/jhet.5570280450

upstream raw materials:

5-benzylthio-1-(3,5-di-O-p-chlorobenzoyl-2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine

5-benzylthio-1,2-dihydro-2-oxopyrazine

2-amino-5-benzylthiopyrazine

5-benzylthio-2-(trimethylsilyloxy)pyrazine