2-amino-5-benzylthiopyrazine

Base Information

• Chemical Name: 2-amino-5-benzylthiopyrazine
• CAS No.: 136743-00-5
• Molecular Formula: C₁₁H₁₁N₃S
• Molecular Weight: 217.294
• Mol file: 136743-00-5.mol

Synonyms:2-amino-5-benzylthiopyrazine

Chemical Property of 2-amino-5-benzylthiopyrazine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-amino-5-benzylthiopyrazine

There total 1 articles about 2-amino-5-benzylthiopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-amino-2-bromopyrazine (59489-71-3) + phenylmethanethiol (100-53-8) → 2-amino-5-benzylthiopyrazine (136743-00-5)

Guidance literature:

With sodium ethanolate; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1002/jhet.5570280450

Reference yield: 46.0%

2-amino-5-benzylthiopyrazine (136743-00-5) → 5-benzylthio-1,2-dihydro-2-oxopyrazine (136743-01-6)

Guidance literature:

With acetic acid; sodium nitrite; In 1,4-dioxane; water; at 5 ℃; for 0.166667h;

DOI:10.1002/jhet.5570280450

Reference yield:

2-amino-5-benzylthiopyrazine (136743-00-5) → 5-benzylthio-2-(trimethylsilyloxy)pyrazine (136743-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / NaNO₂, AcOH / H₂O; dioxane / 0.17 h / 5 °C

2: 93 percent / (NH₄)2SO₄ / 1.5 h / Heating

With ammonium sulfate; acetic acid; sodium nitrite; In 1,4-dioxane; water;

DOI:10.1002/jhet.5570280450

upstream raw materials:

5-amino-2-bromopyrazine

phenylmethanethiol

Downstream raw materials:

5-benzylthio-1,2-dihydro-2-oxopyrazine

5-benzylthio-2-(trimethylsilyloxy)pyrazine

5-benzylthio-1-(2-deoxy-α-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine

5-benzylthio-1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine