3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester

Base Information

• Chemical Name: 3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester
• CAS No.: 1486547-58-3
• Molecular Formula: C₄₀H₅₃ClO₆
• Molecular Weight: 665.31
• Mol file: 1486547-58-3.mol

Synonyms:3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester

Chemical Property of 3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester

There total 5 articles about 3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(benzyloxycarbonyloxy)-7-(methylthiomethoxy)ursodeoxycholic acid benzyl ester (1486547-57-2) → 3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester (1486547-58-3)

Guidance literature:

With thionyl chloride; In dichloromethane; at 100 ℃; for 0.5h; Microwave irradiation;

DOI:10.1002/cmdc.201300059

Reference yield:

benzyl bromide (100-39-0) → 3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester (1486547-58-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 3 h / 80 °C

2: pyridine / dichloromethane / 1.5 h

3: acetic anhydride; acetic acid / 24 h / 20 °C

4: thionyl chloride / dichloromethane / 0.5 h / 100 °C / Microwave irradiation

With pyridine; thionyl chloride; acetic anhydride; potassium carbonate; acetic acid; In dichloromethane; acetonitrile;

DOI:10.1002/cmdc.201300059

Reference yield:

benzyl (4R)-4-((3R,7S,10S,13R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (111992-93-9) → 3-(benzyloxycarbonyloxy)-7-(chloromethoxy)ursodeoxycholic acid benzyl ester (1486547-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1.5 h

2: acetic anhydride; acetic acid / 24 h / 20 °C

3: thionyl chloride / dichloromethane / 0.5 h / 100 °C / Microwave irradiation

With pyridine; thionyl chloride; acetic anhydride; acetic acid; In dichloromethane;

DOI:10.1002/cmdc.201300059

upstream raw materials:

3-(benzyloxycarbonyloxy)-7-(methylthiomethoxy)ursodeoxycholic acid benzyl ester

benzyl bromide

ursodeoxycholic acid

benzyl (4R)-4-((3R,7S,10S,13R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate