methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate

Base Information

• Chemical Name: methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate
• CAS No.: 718615-77-1
• Molecular Formula: C₁₂H₁₆O₆
• Molecular Weight: 256.255
• Mol file: 718615-77-1.mol

Synonyms:methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate

Chemical Property of methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate

There total 1 articles about methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester (66417-42-3) → methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate (718615-77-1)

Guidance literature:

With methanesulfonamide; AD-mix-β; In tert-butyl alcohol; at 0 ℃; for 24h;

DOI:10.1039/b403081h

Reference yield: 84.0%

methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate (718615-77-1) → methyl (2S)-3-(2,4-dimethoxyphenyl)-2-hydroxypropionate (718615-72-6)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1039/b403081h

Reference yield:

methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate (718615-77-1) → methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate (718615-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₃SiH; CF₃COOH / CH₂Cl₂ / 0.17 h / 0 °C

2: 99 percent / imidazole; DMAP / dimethylformamide / 36 h / 20 °C

With 1H-imidazole; triethylsilane; dmap; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b403081h

upstream raw materials:

(E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester

Downstream raw materials:

methyl (2S)-3-(2,4-dimethoxyphenyl)-2-hydroxypropionate

methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate

(2S)-3-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionic acid

O-methyl (2S)-3-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropiohydroxamate