methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate

Base Information

• Chemical Name: methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate
• CAS No.: 718615-78-2
• Molecular Formula: C₂₁H₃₆O₅Si
• Molecular Weight: 396.599
• Mol file: 718615-78-2.mol

Synonyms:methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate

Chemical Property of methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate

There total 3 articles about methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

triisopropylsilyl chloride (13154-24-0) + methyl (2S)-3-(2,4-dimethoxyphenyl)-2-hydroxypropionate (718615-72-6) → methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate (718615-78-2)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 36h;

DOI:10.1039/b403081h

Reference yield:

(E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester (66417-42-3) → methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate (718615-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / AD-mix-β; aq. CH3SO2NH2 / 2-methyl-propan-2-ol / 24 h / 0 °C

2: 84 percent / Et₃SiH; CF₃COOH / CH₂Cl₂ / 0.17 h / 0 °C

3: 99 percent / imidazole; DMAP / dimethylformamide / 36 h / 20 °C

With 1H-imidazole; triethylsilane; dmap; methanesulfonamide; AD-mix-β; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation;

DOI:10.1039/b403081h

Reference yield:

methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate (718615-77-1) → methyl (2S)-2-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionate (718615-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₃SiH; CF₃COOH / CH₂Cl₂ / 0.17 h / 0 °C

2: 99 percent / imidazole; DMAP / dimethylformamide / 36 h / 20 °C

With 1H-imidazole; triethylsilane; dmap; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b403081h

upstream raw materials:

triisopropylsilyl chloride

methyl (2S)-3-(2,4-dimethoxyphenyl)-2-hydroxypropionate

(E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester

methyl (2S,3R)-3-(2,4-dimethoxyphenyl)-2,3-dihydroxypropionate

Downstream raw materials:

O-methyl (2S)-3-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropiohydroxamate

(2S)-3-(2,4-dimethoxyphenyl)-2-triisopropylsilanyloxypropionic acid