7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

Base Information

Chemical Name:7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine
CAS No.:1588424-22-9
Molecular Formula:C₁₇H₁₅ClFN₃O
Molecular Weight:331.777
Hs Code.:

Synonyms:7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

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Technology Process of 7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

There total 10 articles about 7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 672931-28-1
2-(2-fluoro-5-methoxyphenyl)acetonitrile

: 959163-01-0
6-chloro-4-ethylamino-pyridine-3-carbaldehyde

: 1588424-22-9
7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1588424-22-9
7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 16.5 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

3: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1588424-22-9
7-chloro-1-ethyl-3-(2-fluoro-5-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

2: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; N,N-dimethyl-formamide;