trans-α-phenylcinnamyl acetoacetate

Base Information

• Chemical Name: trans-α-phenylcinnamyl acetoacetate
• CAS No.: 77060-85-6
• Molecular Formula: C₁₉H₁₈O₃
• Molecular Weight: 294.35
• Mol file: 77060-85-6.mol

Synonyms:trans-α-phenylcinnamyl acetoacetate

Chemical Property of trans-α-phenylcinnamyl acetoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-α-phenylcinnamyl acetoacetate

There total 2 articles about trans-α-phenylcinnamyl acetoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (85920-63-4) + α-phenylcinnamyl alcohol (22835-64-9) → trans-α-phenylcinnamyl acetoacetate (77060-85-6)

Guidance literature:

In benzene; for 30h; Heating;

DOI:10.1021/jo00323a003

Reference yield:

(E)-2,3-diphenylpropenoic acid (91-48-5) → trans-α-phenylcinnamyl acetoacetate (77060-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / LiAlH₄ / diethyl ether / 1 h / Heating

2: 100 percent / benzene / 30 h / Heating

With lithium aluminium tetrahydride; In diethyl ether; benzene;

DOI:10.1021/jo00323a003

Reference yield: 47.0%

trans-α-phenylcinnamyl acetoacetate (77060-85-6) → α-phenylcinnamyl alcohol (22835-64-9) + trans-α-phenylcinnamyl diazoacetate (77060-87-8)

Guidance literature:

With sodium hydroxide; 4-toluenesulfonyl azide; tetramethylammonium bromide; In benzene; for 54h; Yield given; Ambient temperature;

DOI:10.1021/jo00323a003

upstream raw materials:

5-(1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

α-phenylcinnamyl alcohol

(E)-2,3-diphenylpropenoic acid

Downstream raw materials:

α-phenylcinnamyl alcohol

trans-α-phenylcinnamyl diazoacetate

methyl t,t-2,3-diphenyl-c-2-formylcyclopropane-r-1-carboxylate

methyl c-2-(hydroxymethyl)-t,t-2,3-diphenylcyclopropane-r-1-carboxylate