1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine

Base Information

• Chemical Name: 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine
• CAS No.: 179050-10-3
• Molecular Formula: C₂₁H₂₅BrN₄O₃S
• Molecular Weight: 493.424
• Mol file: 179050-10-3.mol

Synonyms:1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine

Chemical Property of 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine

There total 4 articles about 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromobenzenesulfonyl chloride (98-58-8) + 1-(1-(4-pyridyl)piperidin-4-ylcarbonyl)piperazine (179051-74-2) → 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine (179050-10-3)

Guidance literature:

With pyridine; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm000139k

Reference yield:

4-carboxy-N-(4'-pyridino) piperidine (93913-86-1) → 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine (179050-10-3)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂ / CH₂Cl₂ / 1 h

2: Et₃N / CH₂Cl₂ / 2 h

3: TFA / CH₂Cl₂ / 3 h / 20 °C

4: Et₃N; pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; thionyl chloride; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm000139k

Reference yield:

1-(4-pyridinyl)piperidin-4-yl carbonyl chloride (168077-29-0) → 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine (179050-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: TFA / CH₂Cl₂ / 3 h / 20 °C

3: Et₃N; pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm000139k

upstream raw materials:

4-bromobenzenesulfonyl chloride

1-(1-(4-pyridyl)piperidin-4-ylcarbonyl)piperazine

4-carboxy-N-(4'-pyridino) piperidine

1-(4-pyridinyl)piperidin-4-yl carbonyl chloride