93913-86-1

Basic information

• Product Name: 1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID
• Synonyms: 1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID;3,4,5,6-TETRAHYDRO-2H-[1,4']BIPYRIDINYL-4-CARBOXYLIC ACID;1-Pyridine-4-yl-piperidine-4-carboxylic acid;93913-86-1
• CAS NO: 93913-86-1
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.24
• Product Categories: Pyridine series;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 93913-86-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 407.9°Cat760mmHg
• Flash Point: 200.5°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 2.2E-07mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID(93913-86-1)
• EPA Substance Registry System: 1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID(93913-86-1)

Safety Data

• Hazardous Substances Data: 93913-86-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 44, p. 7095, 1988 DOI: 10.1016/S0040-4020(01)86078-6

InChI:InChI=1/C11H14N2O2/c14-11(15)9-3-7-13(8-4-9)10-1-5-12-6-2-10/h1-2,5-6,9H,3-4,7-8H2,(H,14,15)

Upstream product

• 121912-29-6 1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester 
• 1126-09-6 4-carbethoxypiperidine 
• 1570-45-2 isonicotinic acid ethylester 
• 7379-35-3 4-chlorpyridine hydrochloride 

Downstream Products

• 1203600-35-4 C₂₁H₂₆N₂O₃ 
• 1203600-36-5 tert-butyl 7-[({4-[(benzyloxy)methyl]-1-(pyridin-4-yl)piperidin-4-yl}carbonyl)oxy]-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1203600-34-3 4-[(benzyloxy)methyl]-1-(pyridin-4-yl)piperidine-4-carboxylic acid 
• 168077-29-0 1-(4-pyridinyl)piperidin-4-yl carbonyl chloride 
• 130658-67-2 4-hydroxymethyl-1-(pyridin-4-yl)piperidine 
• 179050-10-3 1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine 

Relevant articles and documents

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity

The design and synthesis of a new class of nonpeptide direct thrombin inhibitors, built on the structure of 1-(pyridin-4-yl)piperidine-4-carboxamide, are described. Starting from a strongly basic 1-amidinopiperidine derivative (6) showing poor thrombin (fIIa) and factor Xa (fXa) inhibition activities, anti-fIIa activity and artificial membrane permeability were considerably improved by optimizing the basic P1 and the X-substituted phenyl P4 binding moieties. Structure-activity relationship studies, usefully complemented with molecular modeling results, led us to identify compound 13b, which showed excellent fIIa inhibition (Ki = 6 nM), weak anti-Xa activity (K i = 5.64 μM), and remarkable selectivity over other serine proteases (e.g., trypsin). Compound 13b showed in vitro anticoagulant activity in the low micromolar range and significant membrane permeability. In mice (ex vivo), 13b demonstrated anticoagulant effects at 2 h after oral dosing (100 mg·kg-1), with a significant 43% prolongation of the activated partial thromboplastin time (aPTT), over controls (P 0.05).

BENZOFURAN DERIVATIVE

The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: -N="or" -CH=; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

POLYMER BOUND 4-DIALKYLAMINO PYRIDINES: SYNTHESYS, CHARACTERIZATION AND CATALYTIC EFFICIENCY.

This work describes the synthesis of 4-carboxy-N-(4'-pyridino) piperidine (CPP), a functionalized analogue of the 4-dialkylamino pyridines, and its anchorage to various polymers by means of an amide bond.Some methods of titration of these supported CPP are pointed out.The efficiency of various supported CPP in the acetylation reaction of 1-methyl cyclohexanol are compared with DMAP as standard.The influence of various factors (polymer type, spacer, loading and temperature) are interpreted in relation to the nature of the microenvironment.An important decrease of the apparent pK of supported CPP as compared to DMAP (about 2 pK units) is assessed.