4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Base Information

Chemical Name:4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin
CAS No.:1443920-08-8
Molecular Formula:C₃₂H₂₉N₃O₁₀
Molecular Weight:615.596
Hs Code.:

Synonyms:4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

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Chemical Property of 4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

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Technology Process of 4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

There total 3 articles about 4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 122089-58-1
4β-azido-4′-demethyl-4′-benzyloxycarbonyl-podophyllotoxin

: 107-19-7
propargyl alcohol

: 1443920-08-8
4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 10h;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 1443920-08-8
4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane

2: boron trifluoride diethyl etherate; ammonia

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 10 h / 20 °C

With copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; ammonia; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 23363-33-9
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin

: 1443920-08-8
4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate; ammonia

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 10 h / 20 °C

With copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; ammonia; sodium L-ascorbate; In water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.03.068