4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate

Base Information

Chemical Name:4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate
CAS No.:1443920-19-1
Molecular Formula:C₂₉H₃₀N₄O₁₀
Molecular Weight:594.578
Hs Code.:

Synonyms:4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate

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Chemical Property of 4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate

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Technology Process of 4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate

There total 5 articles about 4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 110-91-8,99108-56-2
morpholine

: 1443920-10-2
4'-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin p-nitrophenyl carbonate

: 1443920-19-1
4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 1443920-08-8
4'-O-demethyl-4'-benzyloxycarbonyl-4β-[(4-hydroxy methyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

: 1443920-19-1
4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C

With pyridine; dmap; triethylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2013.03.068

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 1443920-19-1
4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin morpholino carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane

2: boron trifluoride diethyl etherate; ammonia

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 10 h / 20 °C

4: pyridine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

5: triethylamine; dmap / dichloromethane / 20 °C

With pyridine; dmap; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; ammonia; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.03.068