(2-bromo-4-chlorophenyl)acetic acid

Base Information

• Chemical Name: (2-bromo-4-chlorophenyl)acetic acid
• CAS No.: 52864-56-9
• Molecular Formula: C8H6BrClO2
• Molecular Weight: 249.491
• Hs Code.: 2916399090
• Mol file: 52864-56-9.mol

Synonyms:(2-bromo-4-chlorophenyl)acetic acid;Benzeneacetic acid,2-broMo-4-chloro-

Chemical Property of (2-bromo-4-chlorophenyl)acetic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 347.657 °C at 760 mmHg
• PKA: 3.92±0.10(Predicted)
• Flash Point: 164.057 °C
• PSA: 37.30000
• Density: 1.72g/cm³
• LogP: 2.72960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Bromo-4-chlorophenyl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-bromo-4-chlorophenyl)acetic acid

There total 5 articles about (2-bromo-4-chlorophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl-2-brom-4-chlorphenylacetat (52864-55-8) → 2-(2-bromo-4-chlorophenyl)acetic acid (52864-56-9)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1002/jhet.5570110312

Reference yield:

2-bromo-4-chlorobenzyl bromide (33924-45-7) → 2-(2-bromo-4-chlorophenyl)acetic acid (52864-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. ethanol

2: H₂SO₄

3: aq. KOH / ethanol / Heating

With potassium hydroxide; sulfuric acid; In ethanol;

DOI:10.1002/jhet.5570110312

Reference yield:

2-(2-bromo-4-chlorophenyl)acetonitrile (52864-54-7) → 2-(2-bromo-4-chlorophenyl)acetic acid (52864-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: aq. KOH / ethanol / Heating

With potassium hydroxide; sulfuric acid; In ethanol;

DOI:10.1002/jhet.5570110312

upstream raw materials:

Ethyl-2-brom-4-chlorphenylacetat

2-bromo-4-chlorobenzyl bromide

2-(2-bromo-4-chlorophenyl)acetonitrile

2-bromo-4-chlorobenzoyl chloride

Downstream raw materials:

2-(2-bromo-4-chlorophenyl)ethan-1-ol

2-bromo-1-(2-bromoethyl)-4-chlorobenzene

1-(2-bromo-4-chlorophenyl)propan-2-one

Refernces

• 1、 Petigara,Yale. "Novel polycyclic heterocycles. XI. Synthesis of 11,12 dihydropyrido [2,1 b] [1,3] benzodiazepines, 6h pyrido[1,2 c] [1,3,5] benzoxadiazepines, and 6h pyrido[1,2 c] [1,3,5]benzothiadiazepines (1)". . p. 331 - 337. Retrieved 2007/10/04.