ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

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Chemical Name:ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate
CAS No.:85083-40-5
Molecular Formula:C₁₆H₁₈BrNO₅
Molecular Weight:384.227
Hs Code.:

Synonyms:ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

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Chemical Property of ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

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Technology Process of ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

There total 6 articles about ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77357-44-9
2,3-Dibromo-5-methoxy-6-methyl-1,4-benzoquinone

: 35150-22-2
(Z)-ethyl 2-(pyrrolidin-2-ylidene)acetate

: 85083-40-5
ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

: 85083-39-2
ethyl (Z)-α-(2-bromo-6-methoxy-5-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/ja00347a055

Reference yield:

: 2207-57-0
2-methoxy-3-methyl-1,4-benzoquinone

: 85083-40-5
ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. Na₂S₂O₄, pH 7.0 / CHCl₃

2: bromine / CHCl₃ / 0.33 h

3: aq. FeCl₃, HCl / methanol / 0.17 h

4: NaH / tetrahydrofuran / 1 h

With hydrogenchloride; sodium dithionite; bromine; iron(III) chloride; sodium hydride; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/ja00347a055

Reference yield:

: 1760-80-1
2-methoxy-3-methylbenzene-1,4-diol

: 85083-40-5
ethyl (Z)-α-(2-bromo-5-methoxy-6-methyl-1,4-benzoquinonyl)-α-2-pyrrolidinylideneacetate

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / CHCl₃ / 0.33 h

2: aq. FeCl₃, HCl / methanol / 0.17 h

3: NaH / tetrahydrofuran / 1 h

With hydrogenchloride; bromine; iron(III) chloride; sodium hydride; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/ja00347a055