ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate

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Chemical Name:ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate
CAS No.:85083-42-7
Molecular Formula:C₁₆H₂₀BrNO₅
Molecular Weight:386.243
Hs Code.:

Synonyms:ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate

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Technology Process of ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate

There total 4 articles about ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77357-44-9
2,3-Dibromo-5-methoxy-6-methyl-1,4-benzoquinone

: 35150-22-2
(Z)-ethyl 2-(pyrrolidin-2-ylidene)acetate

: 85083-42-7
ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate

: 85083-41-6
ethyl (Z)-2-bromo-3,6-dihydroxy-4-methoxy-5-methyl-α-2-pyrrolidinylidenebenzeneacetate

Guidance literature:: With sodium dithionite; sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 1 h;
DOI:10.1021/ja00347a055

Reference yield:

: 2207-57-0
2-methoxy-3-methyl-1,4-benzoquinone

: 85083-42-7
ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. Na₂S₂O₄, pH 7.0 / CHCl₃

2: bromine / CHCl₃ / 0.33 h

3: aq. FeCl₃, HCl / methanol / 0.17 h

4: 1.) NaH, 2.) aq. Na₂S₂O₄, pH 7.0 / 1.) THF, 1 h

With hydrogenchloride; sodium dithionite; bromine; iron(III) chloride; sodium hydride; In methanol; chloroform;
DOI:10.1021/ja00347a055

Reference yield:

: 1760-80-1
2-methoxy-3-methylbenzene-1,4-diol

: 85083-42-7
ethyl (Z)-2-bromo-3,6-dihydroxy-5-methoxy-4-methyl-α-2-pyrrolidinylidenebenzeneacetate

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / CHCl₃ / 0.33 h

2: aq. FeCl₃, HCl / methanol / 0.17 h

3: 1.) NaH, 2.) aq. Na₂S₂O₄, pH 7.0 / 1.) THF, 1 h

With hydrogenchloride; sodium dithionite; bromine; iron(III) chloride; sodium hydride; In methanol; chloroform;
DOI:10.1021/ja00347a055