(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

Base Information

Chemical Name:(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide
CAS No.:1434815-73-2
Molecular Formula:C₂₀H₂₆ClFN₂O₂S
Molecular Weight:412.956
Hs Code.:

Synonyms:(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

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Chemical Property of (R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

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Technology Process of (R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

There total 12 articles about (R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446-33-3
5-Fluoro-2-nitrotoluene

: 1434815-73-2
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dimethyl sulfoxide / 4 h / 110 °C

2: hydrogen; palladium on activated charcoal / methanol; ethyl acetate

With palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1434722-50-5
(R)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-amide

: 1434815-73-2
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dimethyl sulfoxide / 4 h / 110 °C

2: hydrogen; palladium on activated charcoal / methanol; ethyl acetate

With palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1434722-54-9
acetic acid 6-chloro-2-fluoro-3-methyl-phenyl ester

: 1434815-73-2
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

Guidance literature:: Multi-step reaction with 9 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

2: silver nitrate / isopropyl alcohol; water / 1 h / 32 °C

3: sodium hydroxide / methanol / 1 h / 50 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

5: titanium(IV) tetraethanolate / dichloromethane / 20 °C / Inert atmosphere

6: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

7: cesium fluoride / acetonitrile; water / 20 °C

8: caesium carbonate / dimethyl sulfoxide / 4 h / 110 °C

9: hydrogen; palladium on activated charcoal / methanol; ethyl acetate

With 1H-imidazole; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydrogen; caesium carbonate; silver nitrate; cesium fluoride; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;