N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

Base Information

Chemical Name:N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide
CAS No.:1434817-80-7
Molecular Formula:C₂₂H₂₈ClFN₂O₃S
Molecular Weight:454.993
Hs Code.:

Synonyms:N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

Suppliers and Price of N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

There total 14 articles about N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434815-73-2
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(4-amino-3-methyl-phenoxy)-phenyl]-propyl}-amide

: 75-36-5
acetyl chloride

: 1434817-80-7
N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1434815-68-5
(R)-2-methyl-propane-2-sulfinic acid {(R)-1-[4-chloro-2-fluoro-3-(3-methyl-4-nitro-phenoxy)-phenyl]-propyl}-amide

: 1434817-80-7
N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / methanol; ethyl acetate

2: triethylamine / dichloromethane / 1 h / 20 °C

With palladium on activated charcoal; hydrogen; triethylamine; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 446-33-3
5-Fluoro-2-nitrotoluene

: 1434817-80-7
N-(4-{6-chloro-2-fluoro-3-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)-propyl]-phenoxy}-2-methyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / dimethyl sulfoxide / 4 h / 110 °C

2: hydrogen; palladium on activated charcoal / methanol; ethyl acetate

3: triethylamine / dichloromethane / 1 h / 20 °C

With palladium on activated charcoal; hydrogen; caesium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;