o-Cyano-cis-zimtsaeure-methylester

Base Information

• Chemical Name: o-Cyano-cis-zimtsaeure-methylester
• CAS No.: 18454-44-9
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.198
• Mol file: 18454-44-9.mol

Synonyms:o-Cyano-cis-zimtsaeure-methylester

Chemical Property of o-Cyano-cis-zimtsaeure-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-Cyano-cis-zimtsaeure-methylester

There total 8 articles about o-Cyano-cis-zimtsaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

o-cyanobromobenzene (2042-37-7) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 2'-cyanocinnamic acid methyl ester (18454-44-9,75746-64-4,18524-80-6)

Guidance literature:

With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide; at 90 ℃; for 24h;

DOI:10.1016/0040-4039(92)88040-C

Reference yield: 92.0%

(Z)-3-(2-cyanophenyl)prop-2-enoic acid (27510-48-1) + methyl iodide (74-88-4) → o-Cyano-cis-zimtsaeure-methylester (18454-44-9)

Guidance literature:

(Z)-3-(2-cyanophenyl)prop-2-enoic acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.166667h;

methyl iodide; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1080/00397910802238809

Reference yield: 80.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + C7H4N3(1-)*BF4(1+) → 2'-cyanocinnamic acid methyl ester (18454-44-9,75746-64-4,18524-80-6)

Guidance literature:

With palladium diacetate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.02.023

upstream raw materials:

methanol

(Z)-3-(2-cyanophenyl)prop-2-enoic acid

methyl iodide

o-cyanobromobenzene

Downstream raw materials:

methyl 12-hydroxy-6-oxo-6H-dibenzo[c,h]chromen-11-carboxylate

(E)-3-(2-Cyano-phenyl)-3-phenyl-acrylic acid methyl ester

3-(2-cyano-phenyl)-3-(1H-indol-5-yl)-propionic acid methyl ester

5-phenyl-1,2,4,5-tetrahydro-benzo[c]azepin-3-one