8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt

Base Information

Chemical Name:8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt
CAS No.:1401994-85-1
Molecular Formula:C₁₉H₂₃NO₅*ClH
Molecular Weight:381.856
Hs Code.:

Synonyms:8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt

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Chemical Property of 8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt

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Technology Process of 8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt

There total 3 articles about 8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 617-52-7
Dimethyl itakonate

: 1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-one

: 1401994-85-1
8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt

Guidance literature:: Dimethyl itakonate; 1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-one; With sodium methylate; In tetrahydrofuran; at 0 - 20 ℃; for 15h;

With hydrogenchloride; water;

Reference yield:

: 36449-75-9
1-(2-bromoethyl)-2-methoxybenzene

: 1401994-85-1
8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2: sodium methylate / tetrahydrofuran / 15 h / 0 - 20 °C

With sodium methylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1401994-85-1
8-[2-(2-methoxyphenyl)ethyl]-3-methyl-2-oxo-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxylic acid, hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2: sodium methylate / tetrahydrofuran / 15 h / 0 - 20 °C

With sodium methylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;