(S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid

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Chemical Name:(S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid
CAS No.:1240522-23-9
Molecular Formula:C₂₀H₂₁N₅O₃
Molecular Weight:379.418
Hs Code.:

Synonyms:(S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid

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Chemical Property of (S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid

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Technology Process of (S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid

There total 4 articles about (S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1240522-05-7
(S)-tert-butyl 1-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

: 298-12-4
Glyoxilic acid

: 1240522-23-9
(S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid

Guidance literature:: (S)-tert-butyl 1-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate; Glyoxilic acid; With acetic acid; In 1,4-dioxane; 1,2-dichloro-ethane; at 70 ℃; for 0.0333333h;

With sodium tris(acetoxy)borohydride; In 1,4-dioxane; 1,2-dichloro-ethane; at 70 ℃; for 0.75h;
DOI:10.1021/ml4000854

Reference yield:

: 1240522-07-9
C₂₃H₂₇N₅O₃

: 1240522-23-9
(S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.1: acetic acid / 1,2-dichloro-ethane; 1,4-dioxane / 0.03 h / 70 °C

2.2: 0.75 h / 70 °C

With acetic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml4000854

Reference yield:

: 23821-37-6
3-oxo-3-(pyridin-4-yl)propanenitrile

: 1240522-23-9
(S)-2-((1-((1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 2.5 h / 60 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / N,N-dimethyl-formamide

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: acetic acid / 1,2-dichloro-ethane; 1,4-dioxane / 0.03 h / 70 °C

4.2: 0.75 h / 70 °C

With pyridine; hydrogenchloride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ml4000854