2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

Base Information

Chemical Name:2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester
CAS No.:147471-14-5
Molecular Formula:C₁₇H₁₈N₂O₄
Molecular Weight:314.341
Hs Code.:

Synonyms:2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

Suppliers and Price of 2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

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Technology Process of 2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

There total 1 articles about 2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 10040-98-9
1-(4-formylphenyl)-1H-imidazole

: 105-53-3
diethyl malonate

: 147471-14-5
2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

Guidance literature:: With piperidine; acetic acid; In benzene; for 28h; Heating;
DOI:10.1021/jm00060a012

Reference yield: 98.0%

: 75-52-5
nitromethane

: 147471-14-5
2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

: 147471-15-6
2<1-<4-(1H-imidazol-1-yl)phenyl>-2-nitroethyl>-1,3-propanedioic acid diethyl ester

Guidance literature:: With 1,1,3,3-tetramethylguanidine; at -20 ℃; for 2h;
DOI:10.1021/jm00060a012

Reference yield:

: 147471-14-5
2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

: 147471-17-8
4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / tetramethylguanidine / 2 h / -20 °C

2: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

3: 98 percent / titanium trichloride, sodium acetate / H₂O; methanol / 2 h

With titanium(III) chloride; 1,1,3,3-tetramethylguanidine; sodium acetate; ammonium formate; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00060a012