phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester

Base Information

• Chemical Name: phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester
• CAS No.: 220453-11-2
• Molecular Formula: C₂₆H₂₃F₃NO₅P
• Molecular Weight: 517.441

Synonyms:phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester

Chemical Property of phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester

Chemical Property:

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Technology Process of phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester

There total 3 articles about phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-phenylglycinol (20989-17-7) → phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester (220453-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / p-toluenesulfonic acid

2: KHMDS, HMPA

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; toluene-4-sulfonic acid;

DOI:10.1021/ja983389n

Reference yield:

6,6,6-trifluoro-5-oxohexanoic acid (184157-09-3) → phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester (220453-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / p-toluenesulfonic acid

2: KHMDS, HMPA

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; toluene-4-sulfonic acid;

DOI:10.1021/ja983389n

Reference yield:

chlorophosphoric acid diphenyl ester (2524-64-3) + (3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one (220453-06-5) → phosphoric acid diphenyl ester 3-phenyl-8a-trifluoromethyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-5-yl ester (220453-11-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane;

DOI:10.1021/ja983389n

upstream raw materials:

chlorophosphoric acid diphenyl ester

(3S,8aS)-3-Phenyl-8a-trifluoromethyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

(2S)-2-phenylglycinol

6,6,6-trifluoro-5-oxohexanoic acid

Downstream raw materials:

(1S,3aS,5aS,6R,7R,9aR)-1-Phenyl-3a-trifluoromethyl-decahydro-oxazolo[3,2-a]quinoline-6,7-dicarboxylic acid dimethyl ester

(1S,3aS,6S,7R)-1-Phenyl-3a-trifluoromethyl-1,2,4,5,6,7,8,9-octahydro-3aH-oxazolo[3,2-a]quinoline-6,7-dicarboxylic acid dimethyl ester

1-phenyl-3a-trifluoromethyl-1,2,4,5,6,7,8,9-octahydro-3aH-oxazolo[3,2-a]quinoline-7-carboxylic acid ethyl ester

3-phenyl-8a-trifluoromethyl-5-vinyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine

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