5-{4-[2-oxo-2-(1-pyrrolidinyl)ethoxy]benzylidene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

Base Information

Chemical Name:5-{4-[2-oxo-2-(1-pyrrolidinyl)ethoxy]benzylidene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
CAS No.:663205-96-7
Molecular Formula:C₁₇H₁₇N₃O₄S
Molecular Weight:359.406
Hs Code.:

Synonyms:5-(4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)benzylidene)-2-thioxodihydro-pyrimidine-4,6(1H,5H)-dione

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Chemical Property of 5-{4-[2-oxo-2-(1-pyrrolidinyl)ethoxy]benzylidene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

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Technology Process of 5-{4-[2-oxo-2-(1-pyrrolidinyl)ethoxy]benzylidene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

There total 2 articles about 5-{4-[2-oxo-2-(1-pyrrolidinyl)ethoxy]benzylidene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 504-17-6,157796-99-1,924832-30-4
4,6-dihydroxy-2-mercaptopyrimidine

: 438229-79-9
4-(2-oxo-2-pyrrolidin-1-ylethoxy)benzaldehyde

: 663205-96-7
5-(4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)benzylidene)-2-thioxodihydro-pyrimidine-4,6(1H,5H)-dione

Guidance literature:: In ethanol; for 2h; Reflux;
DOI:10.1016/j.bioorg.2020.104198

Reference yield:

: 20266-00-6
chloroacetic acid pyrrolidide

: 663205-96-7
5-(4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)benzylidene)-2-thioxodihydro-pyrimidine-4,6(1H,5H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 6 h / Reflux

2: ethanol / 2 h / Reflux

With potassium carbonate; In ethanol; acetonitrile;
DOI:10.1016/j.bioorg.2020.104198