(R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide

Base Information

Chemical Name:(R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide
CAS No.:1012054-83-9
Molecular Formula:C₂₃H₂₈N₄O₄
Molecular Weight:424.5
Hs Code.:

Synonyms:(R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide

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Chemical Property of (R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide

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Technology Process of (R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide

There total 7 articles about (R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1012057-67-8
(R)-ethyl 6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)hexanoate

: 1012054-83-9
(R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide

Guidance literature:: (R)-ethyl 6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)hexanoate; With hydroxylamine; In methanol; at 20 ℃; for 0.5h;

With acetic acid; In methanol;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1012054-83-9
(R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3: hydroxylamine / methanol / 0.5 h / 20 °C

With hydroxylamine; potassium carbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 179688-53-0
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

: 1012054-83-9
(R)-N-hydroxy-6-(7-methoxy-4-(1-phenylethylamino)quinazolin-6-yloxy)-hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / Heating / reflux

2: isopropyl alcohol / 60 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

4: hydroxylamine / methanol / 0.5 h / 20 °C

With hydroxylamine; potassium carbonate; trichlorophosphate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;