(3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone

Base Information

Chemical Name:(3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone
CAS No.:718610-77-6
Molecular Formula:C₂₆H₃₃N₃O₄S
Molecular Weight:483.632
Hs Code.:

Synonyms:(3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone

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Chemical Property of (3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone

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Technology Process of (3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone

There total 9 articles about (3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 718610-76-5
1-[3-(N-methanesulphonylpiperidin-4-yl)propenyl]-(4S,SR)-3,4-dimethyl-4-phenyl-imidazolidin-2-one

: 100-58-3
phenylmagnesium bromide

: 718610-77-6
(3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone

Guidance literature:: phenylmagnesium bromide; With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃;

1-[3-(N-methanesulphonylpiperidin-4-yl)propenyl]-(4S,SR)-3,4-dimethyl-4-phenyl-imidazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2011.12.117

Reference yield:

: 833491-23-9
(4R,5S)-1,5-dimethyl-3-{(2E)-3-[1-(methylsulfonyl)piperidin-4-yl]prop-2-enoyl}-4-phenylimidazolidin-2-one

: 100-58-3
phenylmagnesium bromide

: 718610-77-6
(3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone

Guidance literature:: phenylmagnesium bromide; With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 1.5h;

(4R,5S)-1,5-dimethyl-3-{(2E)-3-[1-(methylsulfonyl)piperidin-4-yl]prop-2-enoyl}-4-phenylimidazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.16667h;

Reference yield:

: di-n-butylboron triflate

: 718610-76-5
1-[3-(N-methanesulphonylpiperidin-4-yl)propenyl]-(4S,SR)-3,4-dimethyl-4-phenyl-imidazolidin-2-one

: 100-58-3
phenylmagnesium bromide

: 718610-77-6
(3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone

Guidance literature:: With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; for 1h;

phenylmagnesium bromide; In tetrahydrofuran; at -78 ℃; for 0.5h;

di-n-butylboron triflate; 1-[3-(N-methanesulphonylpiperidin-4-yl)propenyl]-(4S,SR)-3,4-dimethyl-4-phenyl-imidazolidin-2-one; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.16667h;