3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester

Base Information

• Chemical Name: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester
• CAS No.: 109462-20-6
• Molecular Formula: C12H24 O5 Si
• Molecular Weight: 248.3483
• Hs Code.: 2931900090
• Mol file: 109462-20-6.mol

Synonyms:Pentanedioicacid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, monomethyl ester (9CI)

Chemical Property of 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester

Chemical Property:

• PSA: 72.83000
• LogP: 2.41460

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester

There total 13 articles about 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

C19H30O5Si → 1-methyl hydrogen 3-<(tert-butyl)dimethylsilyloxy>glutarate (109462-20-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 70 ℃; for 3h; under 22801.5 Torr;

Reference yield: 84.0%

(+/-)-methyl tert-butyldimethylsilyl 3-<(tert-butyldimethylsilyl)oxy>pentanedioate (91465-61-1) → 1-methyl hydrogen 3-<(tert-butyl)dimethylsilyloxy>glutarate (109462-20-6)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; water; for 1h; Ambient temperature;

DOI:10.1002/hlca.19870700118

Reference yield:

methanol (67-56-1) + 3-(tert-butyldimethylsilyloxy)glutaric anhydride (91424-40-7) → 1-methyl hydrogen 3-<(tert-butyl)dimethylsilyloxy>glutarate (109462-20-6)

Guidance literature:

With sodium; at 0 ℃; for 1h;

DOI:10.1021/jo00193a044

upstream raw materials:

methanol

3-(tert-butyldimethylsilyloxy)glutaric anhydride

(+/-)-methyl tert-butyldimethylsilyl 3-<(tert-butyldimethylsilyl)oxy>pentanedioate

3-(tert-butyl-dimethyl-silanyloxy)-pentanedioic acid dimethyl ester

Downstream raw materials:

β-<(tert-butyldimethylsilyl)oxy>-δ-oxopimelic acid, methyl benzyl diester

(R)-3-(tert-butyldimethylsilanyloxy)-4-{3-[3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)ureido]benzyloxycarbonylamino}butyric acid methyl ester

methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-ketobutyrate

methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-hydroxybutyrate