((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid

Base Information

• Chemical Name: ((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid
• CAS No.: 776306-98-0
• Molecular Formula: C₁₃H₂₀O₃
• Molecular Weight: 224.3
• Mol file: 776306-98-0.mol

Synonyms:((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid

Chemical Property of ((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid

There total 1 articles about ((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

methyl 2-[(1S,2R,6R)-2-hydroxy-6-isopropenyl-3-methyl-cyclohex-3-enyl]acetate (666740-75-6) + methyl iodide (74-88-4) → methyl 2-[(1S,2R,6R)-6-isopropenyl-2-methoxy-3-methyl-cyclohex-3-en-1-yl]acetate (666740-73-4) + ((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid (776306-98-0)

Guidance literature:

methyl 2-[(1S,2R,6R)-2-hydroxy-6-isopropenyl-3-methyl-cyclohex-3-enyl]acetate; With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; mineral oil; for 6h; Reflux;

Reference yield: 90.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + ((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid (776306-98-0) → methyl 2-[(1S,2R,6R)-6-isopropenyl-2-methoxy-3-methyl-cyclohex-3-en-1-yl]acetate (666740-73-4)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1016/j.tetlet.2004.07.103

Reference yield:

((1S,2R,6R)-6-Isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl)-acetic acid (776306-98-0) → methyl 2-[(1S,2R,6R)-6-isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl]propionate (776306-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diethyl ether / 0 °C

2: LDA / tetrahydrofuran / 6 h / 0 - 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.tetlet.2004.07.103

upstream raw materials:

methyl 2-[(1S,2R,6R)-2-hydroxy-6-isopropenyl-3-methyl-cyclohex-3-enyl]acetate

methyl iodide

Downstream raw materials:

methyl 2-[(1S,2R,6R)-6-isopropenyl-2-methoxy-3-methyl-cyclohex-3-en-1-yl]acetate

methyl 2-[(1S,2R,6R)-6-isopropenyl-2-methoxy-3-methyl-cyclohex-3-enyl]propionate