(R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

Base Information

Chemical Name:(R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione
CAS No.:760983-13-9
Molecular Formula:C₁₄H₁₇FN₂O₃S
Molecular Weight:312.365
Hs Code.:

Synonyms:(R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

Suppliers and Price of (R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

There total 1 articles about (R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 60456-26-0
(R)-glycidyl butyrate

: 4-(2-fluoro-4-isothiocyanato-phenyl)-morpholine

: 760983-13-9
(R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

Guidance literature:: (R)-glycidyl butyrate; 4-(2-fluoro-4-isothiocyanato-phenyl)-morpholine; With Triphenylphosphine oxide; lithium bromide; In xylene; at 110 - 115 ℃; for 1h;

With sodium methylate; In methanol; at 26 - 28 ℃; for 2h; Further stages.;
DOI:10.1016/j.tetlet.2004.06.090

Reference yield: 70.0%

: 124-63-0
methanesulfonyl chloride

: 760983-13-9
(R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

: 760983-17-3
Methanesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-thioxo-oxazolidin-5-ylmethyl ester

Guidance literature:: With TEA; In dichloromethane; at 0 - 5 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2004.06.090

Reference yield:

: 760983-13-9
(R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione

: 760983-21-9
(R)-5-Azidomethyl-3-(3-fluoro-4-morpholin-4-yl-phenyl)-oxazolidine-2-thione

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / TEA / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 81 percent / NaN₃ / dimethylformamide / 1 h / 60 - 70 °C

With sodium azide; TEA; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.06.090