N-(2-chloropyridin-4-yl)acetamide

Base Information

• Chemical Name: N-(2-chloropyridin-4-yl)acetamide
• CAS No.: 13602-82-9
• Molecular Formula: C7H7ClN2O
• Molecular Weight: 170.598
• Hs Code.: 29339900
• DSSTox Substance ID: DTXSID60365980
• Wikidata: Q72434029
• Mol file: 13602-82-9.mol

Synonyms:N-(2-chloropyridin-4-yl)acetamide;13602-82-9;4-Acetamido-2-chloropyridine;N-(2-chloro-4-pyridinyl)acetamide;MFCD00234294;N-(2-chloro-4-pyridyl)acetamide;SCHEMBL4175713;DTXSID60365980;DFUPWNHYRNYOHQ-UHFFFAOYSA-N;STL227860;AKOS000267445;DS-0670;N-(2-chloranylpyridin-4-yl)ethanamide;AC-20555;SY064864;CS-0084783;FT-0617369;EN300-129547;A807017;AC-907/25004649;J-514270;F1921-0023;Z1201619919

Chemical Property of N-(2-chloropyridin-4-yl)acetamide

Chemical Property:

• Vapor Pressure: 1.15E-05mmHg at 25°C
• Refractive Index: 1.597
• Boiling Point: 369.9 °C at 760 mmHg
• PKA: 13.23±0.70(Predicted)
• Flash Point: 177.5 °C
• PSA: 41.99000
• Density: 1.336 g/cm³
• LogP: 1.76640
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.0246905
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

99% HPLC ^*data from raw suppliers

N-(2-Chloropyridin-4-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC(=NC=C1)Cl

Technology Process of N-(2-chloropyridin-4-yl)acetamide

There total 2 articles about N-(2-chloropyridin-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) + acetyl chloride (75-36-5) → N-(2-chloro-pyridin-4-yl)-acetamide (13602-82-9)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2010.02.088

Reference yield:

→ N-(2-chloro-pyridin-4-yl)-acetamide (13602-82-9)

Guidance literature:

entspr. Amin, Ac2O;

Reference yield: 66.0%

N-(2-chloro-pyridin-4-yl)-acetamide (13602-82-9) + methyl iodide (74-88-4) → N-(2-chloro-pyridin-4-yl)-N-methyl-acetamide (892867-22-0)

Guidance literature:

With potassium hydroxide; In acetone; at 20 ℃; for 2h;

upstream raw materials:

4-Amino-2-chloropyridine

acetyl chloride

Downstream raw materials:

N-(2-chloro-pyridin-4-yl)-N-methyl-acetamide

C₁₄H₁₂ClFN₂O