1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

Base Information

Chemical Name:1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene
CAS No.:144412-87-3
Molecular Formula:C₂₂H₃₄O₄Si
Molecular Weight:390.595
Hs Code.:

Synonyms:1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

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Chemical Property of 1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

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Technology Process of 1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

There total 6 articles about 1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 144412-86-2
1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-<(ethoxycarbonyl)methyl>cyclohex-1-ene

: 144412-87-3
1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jo00051a021

Reference yield:

: 6642-34-8
6-bromopiperonyl alcohol

: 144412-87-3
1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi / 1) ether, hexane, -78 deg C, 5 min, 2) a) to 23 deg C, 2 h, b) 23 deg C, 8 h

2: 89 percent / imidazole / tetrahydrofuran / 8 h / 23 °C

3: 74 percent / LiClO₄ / diethyl ether / 24 h / 23 °C

4: 97 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; lithium perchlorate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00051a021

Reference yield:

: 930-68-7
cyclohexenone

: 144412-87-3
1-<2-<<(tert-Butyldimethylsilyl)oxy>methyl>-4,5-(methylenedioxy)phenyl>-3-(2-hydroxyethyl)cyclohex-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi / 1) ether, hexane, -78 deg C, 5 min, 2) a) to 23 deg C, 2 h, b) 23 deg C, 8 h

2: 89 percent / imidazole / tetrahydrofuran / 8 h / 23 °C

3: 74 percent / LiClO₄ / diethyl ether / 24 h / 23 °C

4: 97 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; lithium perchlorate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00051a021