(E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide

Base Information

Chemical Name:(E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide
CAS No.:1508307-31-0
Molecular Formula:C₁₉H₁₅F₃N₂O
Molecular Weight:344.336
Hs Code.:

Synonyms:(E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide

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Chemical Property of (E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide

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Technology Process of (E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide

There total 4 articles about (E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1508307-31-0
(E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 42924-82-3
(E)-3-(1H-indol-3-yl)-2-methylacrylic acid

: 1508307-31-0
(E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: (E)-3-(1H-indol-3-yl)-2-methylacrylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

4-trifluoromethylphenylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.01.062

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1508307-31-0
(E)-3-(1H-indol-3-yl)-2-methyl-N-(4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 5 °C / Inert atmosphere; Reflux

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide; dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Wittig Olefination;
DOI:10.1016/j.ejmech.2014.01.062