Ethyl 3,4-dichloro-beta-hydroxybenzenepropanoate

Base Information

• Chemical Name: Ethyl 3,4-dichloro-beta-hydroxybenzenepropanoate
• CAS No.: 62547-78-8
• Molecular Formula: C₁₁H₁₂Cl₂O₃
• Molecular Weight: 263.12
• DSSTox Substance ID: DTXSID701254722
• Mol file: 62547-78-8.mol

Synonyms:62547-78-8;Ethyl 3,4-dichloro-beta-hydroxybenzenepropanoate;ethyl 3-(3,4-dichlorophenyl)-3-hydroxypropanoate;SCHEMBL8771122;DTXSID701254722;AKOS011681058;SY348583

Chemical Property of Ethyl 3,4-dichloro-beta-hydroxybenzenepropanoate

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 262.0163496
• Heavy Atom Count: 16
• Complexity: 235

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)CC(C1=CC(=C(C=C1)Cl)Cl)O

Technology Process of Ethyl 3,4-dichloro-beta-hydroxybenzenepropanoate

There total 2 articles about Ethyl 3,4-dichloro-beta-hydroxybenzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl bromoacetate (105-36-2) + 3,4-dichlorobenzaldehyde (6287-38-3) → C11H12Cl2O3 (62547-78-8)

Guidance literature:

With hydrogenchloride; zinc; In tetrahydrofuran; water; for 0.5h; Reflux;

DOI:10.1016/j.ejmech.2013.07.047

Reference yield:

ethyl acetate (141-78-6) + 3,4-dichlorobenzaldehyde (6287-38-3) → C11H12Cl2O3 (62547-78-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jm7012216

Reference yield: 82.0%

C11H12Cl2O3 (62547-78-8) → 3-(3,4-dichlorophenyl)-3-hydroxypropionylhydroxamic acid

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; at 0 ℃;

DOI:10.1016/j.ejmech.2013.07.047

upstream raw materials:

ethyl acetate

3,4-dichlorobenzaldehyde

ethyl bromoacetate

Downstream raw materials:

1-(3,4-dichlorophenyl)-1,3-propanediol