5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

Base Information

Chemical Name:5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide
CAS No.:1563184-55-3
Molecular Formula:C₁₅H₂₁Cl₂N₃O₆S
Molecular Weight:442.32
Hs Code.:

Synonyms:5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

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Chemical Property of 5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

Chemical Property:

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Technology Process of 5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

There total 6 articles about 5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: C₁₂H₁₄Cl₂N₂O₆S

: 1563184-55-3
5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

Guidance literature:: In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 1563184-55-3
5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 3 h / 75 °C / Inert atmosphere

2: sodium dihydrogen phosphate monohydrate; dihydrogen peroxide; sodium chlorite; hydrogenchloride / acetonitrile; water / 0 - 20 °C

3: sulfuric acid; nitric acid / 4 h / 45 °C

4: dimethyl sulfoxide / 2 h / 45 °C

5: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

6: dichloromethane; tetrahydrofuran / 0.33 h / 0 °C

With hydrogenchloride; sodium chlorite; thionyl chloride; sodium dihydrogen phosphate monohydrate; sulfuric acid; dihydrogen peroxide; nitric acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 185945-88-4
3-fluoro-4-(methylsulfonyl)benzoic acid

: 1563184-55-3
5-(bis(2-chloroethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 4 h / 45 °C

2: dimethyl sulfoxide / 2 h / 45 °C

3: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

4: dichloromethane; tetrahydrofuran / 0.33 h / 0 °C

With thionyl chloride; sulfuric acid; nitric acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;