2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate
CAS No.:1039136-57-6
Molecular Formula:C₁₈H₂₅F₂NO₃Si
Molecular Weight:369.484
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

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Chemical Property of 2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

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Technology Process of 2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

There total 4 articles about 2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 2,2-difluoro-N-(4-methoxy-phenyl)-pent-4-enimidoyl iodide

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 201230-82-2
carbon monoxide

: 1039136-57-6
2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; In N,N-dimethyl-formamide; toluene; at 20 ℃; under 760 Torr;
DOI:10.1021/ol061733c

Reference yield:

: 55039-89-9
2,2-difluoropent-4-enoic acid

: 1039136-57-6
2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1: Ph₃P; Et₃N; CCl₄ / 3 h / Heating

2: NaI / acetone / 20 °C

3: 52 percent / K₂CO₃; Pd₂(dba)3*CHCl₃ / toluene; dimethylformamide / 20 °C / 760 Torr

With tetrachloromethane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; triethylamine; triphenylphosphine; sodium iodide; In N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ol061733c

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1039136-57-6
2-(trimethylsilyl)ethyl 3,3-difluoro-2-[(4-methoxyphenyl)imino]-5-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1: Ph₃P; Et₃N; CCl₄ / 3 h / Heating

2: NaI / acetone / 20 °C

3: 52 percent / K₂CO₃; Pd₂(dba)3*CHCl₃ / toluene; dimethylformamide / 20 °C / 760 Torr

With tetrachloromethane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; triethylamine; triphenylphosphine; sodium iodide; In N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ol061733c