253353-10-5

Basic information

• Product Name: 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate
• Synonyms: 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate
• CAS NO: 253353-10-5
• Molecular Weight: 517.576
• Mol File: 253353-10-5.mol

Chemical Properties

• CAS DataBase Reference: 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate(253353-10-5)
• EPA Substance Registry System: 1,1-dimethylethyl (αS)-β-(1,1-dimethylethoxycarbonyl)-3,4-dioxo-2-(1-methylethoxy)-α-(phenylmethyloxycarbonylamino)-1-cyclobutene-1-propionate(253353-10-5)

Safety Data

• Hazardous Substances Data: 253353-10-5(Hazardous Substances Data)

Upstream product

• 253353-09-2 1,1-dimethylethyl (αS)-2,3-bis(1-methylethoxy)-β-(1,1-dimethylethoxycarbonyl)-1-hydroxy-4-oxo-α-phenylmethyloxycarbonylamino-2-cyclobutene-1-propionate 

Downstream Products

• 253353-11-6 (αS)-3,4-dioxo-2-(1-methylethoxy)-α-phenylmethyloxycarbonylamino-1-cyclobutene-1-propionic acid 
• 253353-33-2 methyl (2'S)-N-(3-(3,4-dioxo-2-(1-methylethyloxy)-1-cyclobutenyl)-1-oxo-2-phenylmethyloxycarbonylpropyl)-L-valinate 
• 253353-26-3 (S)-3,4-dioxo-2-hydroxy-α-phenylmethyloxycarbonylamino-1-cyclobutene-1-propionic acid 

Relevant articles and documents

Efficient synthesis of a novel 4-hydroxy-2,3-dioxocyclobut-1-enyl group containing amino acids

matrix presented Syntheses of novel amino acids possessing a squaryl group, 1-3, in an optically active form are described. The syntheses of 1-3 were conducted by a concise route involving (1) an aldol addition of an enolate derived from Gly, L-Asp, or L-Glu to diisopropyl squarate (4) and (2) an efficient decarboxylation of the aldol adducts based on the electron-withdrawing property of the squaryl group. Introducing N-protected group to 2 and 3 and peptide formation reactions are also described.