methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

Base Information

Chemical Name:methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate
CAS No.:1021438-11-8
Molecular Formula:C₃₇H₄₈N₄O₈S
Molecular Weight:708.876
Hs Code.:

methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

Synonyms:methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

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Chemical Property of methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

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Technology Process of methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

There total 8 articles about methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1021437-85-3
methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9,20-trioxo-3,4,6,7,8,9,12,13,14,15,19,20-dodecahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

: 105687-33-0
4-(iodomethyl)-2-methylthiazole

: 1021438-11-8
methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

Guidance literature:: With silver(l) oxide; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h;
DOI:10.1016/j.bmcl.2012.08.106

Reference yield:

: 39238-07-8
4-(chloromethyl)-2-methyl-1,3-thiazole

: 1021437-83-1
methyl (2R,4S,7S,14E)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9,20-trioxo-3,4,6,7,8,9,12,13,19,20-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

: 1021438-11-8
methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

Guidance literature:: With silver(l) oxide; In N,N-dimethyl-formamide; at 100 ℃; for 15h;

Reference yield:

: 957475-62-6
6-bromo-4-hydroxy-7-methoxyquinolin-2(1H)-one

: 1021438-11-8
methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 6.5 h / 60 °C / Inert atmosphere

2: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 1 h / Reflux

3: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

5: Zhan catalyst-1B / dichloromethane / 32 h / 20 °C / Reflux

6: palladium on activated charcoal; hydrogen / ethanol / Inert atmosphere

7: silver(l) oxide / N,N-dimethyl-formamide / 1.5 h / 100 °C

With hydrogenchloride; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.106