3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose

Base Information

• Chemical Name: 3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose
• CAS No.: 1393464-52-2
• Molecular Formula: C₂₂H₂₈O₈S
• Molecular Weight: 452.526
• Mol file: 1393464-52-2.mol

Synonyms:3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose

Chemical Property of 3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose

There total 1 articles about 3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 3-O-benzyl-4-[(benzyloxy)methyl]-1,2-O-(1-methylethylidene)-5-O-(methylsulfonyl)-β-L-lyxofuranose (219854-34-9) → 3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose (1393464-52-2)

Guidance literature:

With toluene-4-sulfonic acid; In water; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo300936g

Reference yield: 74.0%

3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose (1393464-52-2) → (1R,4R,6R,7R)-7-benzyloxy-4-benzyloxymethyl-6-methoxy-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:

With potassium carbonate; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo300936g

Reference yield:

3,5-di-O-benzyl-4-mesyloxymethyl-1-O-methyl-β-D-ribofuranose (1393464-52-2) → (2R,3R,4R)-3-(benzyloxy)-4-[(benzyloxy)methyl]tetrahydro-4-hydroxyfuran-2-carbaldehyde (221229-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 0 - 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / tetrahydrofuran; water / 20 °C / Inert atmosphere

With potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water;

DOI:10.1021/jo300936g

upstream raw materials:

methanol

3-O-benzyl-4-[(benzyloxy)methyl]-1,2-O-(1-methylethylidene)-5-O-(methylsulfonyl)-β-L-lyxofuranose

Downstream raw materials:

(2R,3R,4R)-3-(benzyloxy)-4-[(benzyloxy)methyl]tetrahydro-4-hydroxyfuran-2-carbaldehyde